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. 2011 Feb 24;74(4):567–573. doi: 10.1021/np100429s

Figure 4.

Figure 4

Austocystin D displays cell-line-selective DNA damage that correlates with cytotoxicity. (a) In-cell Western showing the effect of austocystin D, doxorubicin, bleomycin, and DMSO (vehicle) on levels of phosphorylated histone H2AX (pH2AX) after 4 h treatment of HCT-15 cells. (b) In-cell Western data showing the effect of austocystin D on pH2AX in SW620, HCT-15, and HeLa cells following 1 h of treatment. 72 h GI50 values are shown for comparison in parentheses. Vertical bars represent SEM.