Table 2.

Left Ventricular Physiology 3 Weeks After Transaortic Constriction

	CON (n = 15)	AC6-KO (n = 11)	p Value
Heart rate (beats/min)	453 ± 14	432 ± 16	0.34
Cardiac output (ml/min)	2.2 ± 0.4*	3.6 ± 0.3†	0.01
Stroke volume (µl)	5 ± 1	8 ± 1	0.05
LV pressure (mm Hg)	87 ± 6	93 ± 5	0.45
Stroke work (mm Hg·µl)	176 ± 45*	490 ± 62†	0.002
LV +dP/dt (mm Hg/s)	2,793 ± 251	3,610 ± 406	0.05
LV −dP/dt (mm Hg/s)	−2,842 ± 343	−3,895 ± 286	0.07
LV end-diastolic pressure (mm Hg)	13 ± 2	7 ± 1	0.03
Tau (ms)	7.1 ± 0.3	6.6 ± 0.2	0.19
LV elastance (mm Hg/µl)	3.8 ± 0.7‡	7.7 ± 0.7*	0.002
PRSW (mm Hg)	26 ± 6§	58 ± 9*	0.02

Elastance is the slope of the end-systolic pressure-volume relationship. p Values are from Student t test (2-tailed). Values shown are mean ± SE.

^*n = 12.

^†n = 7.

^‡n = 9.

^§n = 8.

LV = left ventricular; PRSW = preload recruitable stroke work.