Table 1.
Descriptive characteristics of each study*
| Adenoma | LA CRC | HI CRC | MEC | All | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |
| Total subjects | 839 | 1170 | 497 | 507 | 426 | 616 | 1549 | 2173 | 3311 | 4466 |
| Sex (%) | ||||||||||
| Men | 515(0.61) | 733(0.63) | 0 | 0 | 255(0.60) | 355(0.58) | 853(0.55) | 1132(0.52) | 1623(0.49) | 2220(0.50) |
| Women | 324(0.39) | 437(0.37) | 497(1.00) | 507(1.00) | 171(0.40) | 261(0.42) | 696(0.45) | 1041(0.48) | 1688(0.51) | 2246(0.50) |
| Race (%) | ||||||||||
| African Americans | 0 | 0 | 67(0.13) | 52(0.10) | 0 | 0 | 315(0.20) | 458(0.21) | 382(0.12) | 510(0.11) |
| Native Hawaiians | 181(0.21) | 233(0.20) | 0 | 0 | 65(0.15) | 83(0.13) | 77(0.05) | 156(0.07) | 323(0.10) | 472(0.11) |
| Japanese Americans | 267(0.32) | 380(0.32) | 0 | 0 | 233(0.55) | 373(0.61) | 542(0.35) | 673(0.31) | 1042(0.31) | 1426(0.32) |
| Latinos | 0 | 0 | 59(0.12) | 43(0.09) | 0 | 0 | 334(0.22) | 481(0.22) | 393(0.12) | 524(0.12) |
| European Americans | 391(0.47) | 557(0.48) | 371(0.75) | 412(0.81) | 128(0.30) | 160(0.26) | 281(0.18) | 405(0.19) | 1171(0.35) | 1534(0.34) |
| Age | ||||||||||
| Mean(sd) | 59.9(8.6) | 61.9(8.4) | 65.6(5.7) | 64.6(6.8) | 64.3(11.8) | 65.0(11.6) | 68.4(8.2) | 66.8(8.1) | 65.3(9.2) | 65.1(8.9) |
| No. unknown | 0 | 0 | 0 | 0 | 0 | 0 | 28 | 0 | 28 | 0 |
| Site | ||||||||||
| Unknown | -- | -- | 0 | 2 | 28 | 30 | ||||
| Rectum | -- | -- | 59 | -- | 120 | -- | 413 | -- | 592 | -- |
| Colon | -- | -- | 438 | -- | 304 | -- | 1108 | -- | 1850 | -- |
| Left colon | -- | -- | 187 | -- | 169 | -- | 509 | -- | 865 | -- |
| Right colon | -- | -- | 248 | -- | 134 | -- | 587 | -- | 969 | -- |
| Other colon | -- | -- | 3 | -- | 1 | -- | 12 | -- | 16 | -- |
| Stage | ||||||||||
| Unknown | -- | -- | 1 | 2 | 28 | 31 | ||||
| In situ | -- | -- | 30 | -- | 42 | -- | 130 | -- | 202 | -- |
| Invasive | -- | -- | 466 | -- | 382 | -- | 1391 | -- | 2239 | -- |
| Localized | -- | -- | 201 | -- | 194 | -- | 694 | -- | 1089 | -- |
| Distant/regional | -- | -- | 264 | -- | 182 | -- | 594 | -- | 1040 | -- |
| Unknown | -- | -- | 1 | -- | 6 | -- | 103 | -- | 110 | -- |
| First-degree family history of colorectal cancer (%) | ||||||||||
| Yes | 151(0.18) | 160(0.14) | 65(0.13) | 57(0.11) | 74(0.17) | 62(0.10) | 182(0.12) | 190(0.09) | 472(0.14) | 469(0.11) |
| No | 688(0.82) | 1010(0.86) | 432(0.87) | 450(0.89) | 352(0.83) | 554(0.90) | 1367(0.88) | 1983(0.91) | 2839(0.86) | 3997(0.89) |
| Smoking status (%) | ||||||||||
| Never | 364(0.43) | 620(0.53) | 221(0.45) | 255(0.5) | 174(0.41) | 289(0.47) | 532(0.34) | 933(0.43) | 1291(0.39) | 2097(0.47) |
| Past | 370(0.44) | 473(0.4) | 215(0.43) | 197(0.39) | 182(0.43) | 260(0.42) | 683(0.44) | 912(0.42) | 1450(0.44) | 1842(0.41) |
| Current | 105(0.13) | 77(0.07) | 61(0.12) | 55(0.11) | 67(0.16) | 62(0.1) | 234(0.15) | 299(0.14) | 467(0.14) | 493(0.11) |
| Unknown | 0 | 0 | 0 | 0 | 3(0.01) | 5(0.01) | 100(0.06) | 29(0.01) | 103(0.03) | 34(0.01) |
| BMI (kg/m2) (%) | ||||||||||
| <23 | 125(0.15) | 256(0.22) | 108(0.22) | 122(0.24) | 149(0.35) | 195(0.32) | 327(0.21) | 536(0.25) | 709(0.21) | 1109(0.25) |
| ≥23–25 | 150(0.18) | 213(0.18) | 86(0.17) | 95(0.19) | 86(0.20) | 120(0.19) | 268(0.17) | 445(0.20) | 590(0.18) | 873(0.20) |
| ≥25–30 | 324(0.39) | 447(0.38) | 160(0.32) | 173(0.34) | 128(0.30) | 219(0.36) | 577(0.37) | 816(0.38) | 1189(0.36) | 1655(0.37) |
| ≥30 | 240(0.29) | 254(0.22) | 143(0.29) | 117(0.23) | 63(0.15) | 82(0.13) | 277(0.18) | 356(0.16) | 723(0.22) | 809(0.18) |
| Unknown | 0 | 0 | 0 | 0 | 0 | 0 | 100(0.06) | 20(0.01) | 100(0.03) | 20(0.004) |
*
Adenoma: The Adenoma Study; LA CRC: The Los Angeles County CRC Case-Control Study; HI CRC: The Hawaii Multiethnic CRC Case-Control Study; MEC: The Multiethnic Cohort.