Figure 2. Effects of riluzole on the spontaneous activity of A-type neurons in the compressed DRG.

(A) Time histogram showing that local application of the I_NaP blocker riluzole reduces the basal firing rate of an A-type fiber in a dose-dependent manner (n = 6; P<0.05). (B) Percent inhibition of spontaneous activity in A-type fibers with respect to the concentration of locally-applied riluzole (µM; n = 6; *P<0.05, **P<0.01, ***P<0.001). (C) Time histogram showing the suppression of spontaneous activity induced by riluzole (100 µM) in an A-type afferent fiber from a compressed DRG. Expanded traces in right panel show firing patterns before (a) and during (b) the drug application.