Table 2.

Occurrence of Late Adverse Gastrointestinal Outcomes by Time Period

		Outcome Occurred After Cancer Diagnosis		Outcome Occurred 5+ Years from Cancer Diagnosis
	Condition	Sur yes #	Sibs Yes #	Yes	Rate‡	95% CI	RR§	95% CI
Upper GI Complications	Ulcer	618	141	401	2.8	2.5 – 3.1	1.5	1.3 – 1.9
	Esophageal Disease	289	47	190	1.3	1.1 – 1.5	2.6	1.8 – 3.5
	Indigestion/ Heartburn	2087	495	1524	11.2	10.6 – 11.8	1.8	1.6 – 1.9
	Nausea/ Vomiting	192	21	97	0.7	0.5 – 0.8	3.3	2.0 – 5.5
	Other Upper GI Trouble	625	107	430	3.0	2.7 – 3.3	2.6	2.1 – 3.3
Liver Conditions	Gallstones & Other Gall Bladder Issues	338	84	285	1.9	1.7 – 2.2	2.0	1.6 – 2.6
	Liver Cirrhosis	42	2	27	0.2	0.1 – 0.3	8.9	2.0 – 40.0
	Jaundice	444	158	84	0.6	0.5 – 0.7	1.3	1.0 – 1.8
	Liver Biopsy	170	3	103	0.7	0.6 – 0.9	24.1	7.5 – 77.8
	Other Liver Trouble	364	11	148	1.0	0.9 – 1.2	13	6.8 – 24.9
Lower GI Complications	Intestinal Polyps/Diverticular Disease	96	20	75	0.5	0.4 – 0.6	2.2	1.3 – 3.7
	Colitis	119	51	87	0.6	0.5 – 0.7	0.9	0.7 – 1.4
	Constipation	921	180	407	2.9	2.6 – 3.2	1.8	1.5 – 2.2
	Diarrhea	664	91	351	2.4	2.2 – 2.7	2.7	2.1 – 3.5
	Rectal/Anal Fistula/Stricture/Other Obstruction Surgery	165	41	98	0.7	0.5 – 0.8	1.5	1.0 – 2.2
	Colostomy/ Ileostomy	121	7	43	0.3	0.2 – 0.4	5.6	2.4 – 13.1
	Other Lower Intestinal Trouble	247	62	185	1.3	1.1 – 1.5	1.8	1.4 – 2.5

Abbreviation: RR, rate ratio;

^*Excludes conditions prior to cancer diagnosis.

^†Includes “not sure” and missing responses.

^{§ ‡}Rate per 1,000 person-years.

^**RR, adjusted for age, sex and race; relative to siblings.