Table 4.

Multivariable Poisson Regression Analysis of Late-onset GI outcomes

	Upper GI Complication		Liver Complications		Lower GI Complication
	RR (95% CI)	P-value	RR (95% CI)	P-value	RR (95% CI)	P-value
Age at Diagnosis
<3 (Ref)
3–9	1.3(1.1 – 1.5)	<.001	2.2(1.5 – 3.2)	<.001	1.2(1.0 – 1.5)	0.09
10+	1.5(1.3 – 1.7)	<.001	2.6(1.8 – 3.8)	<.001	1.3(1.0 – 1.6)	0.03
Abdominal Radiation
No(Ref)
Yes	1.3(1.2 – 1.4)	<.001			1.3(1.1 – 1.5)	0.005
Alkylating Agents Score
None(Ref) (AA Score=0)
Low dose(AA Score=1)			1.0(0.7 – 1.4)	0.95	1.2(0.9 – 1.4)	0.17
Medium dose(AA Score=2)			1.2(0.9 – 1.6)	0.32	1.2(0.9 – 1.4)	0.22
High dose(AA Score=3)			1.8(1.3 – 2.4)	<.001	1.5(1.1 – 1.8)	0.002
Anthracycline
None(Ref)
≤100	1.1(0.9 – 1.5)	0.38	1.4(0.7 – 2.6)	0.30
101–200	1.3(1.1 – 1.6)	0.002	1.1(0.6 – 1.8)	0.80
201–300	1.1(0.9 – 1.4)	0.25	2.1(1.5 – 3.0)	<.001
>300	1.2(1.1 – 1.4)	0.007	1.3(1.0 – 1.8)	0.05
Abdominal Surgery
No(Ref)
Yes			1.3(1.1 – 1.7)	0.02
Total Body Irradiation
No(Ref)
Yes			3.8(2.0 – 7.2)	<.001