Table 2.
Sample Demographics, Cognitive Performance, and Medical History by Total Estradiol Quartile in Older Men.
| Total Sample (N=185) | Estradiol* Quartile 1 (N=46) | Estradiol Quartile 2 (N=46) | Estradiol Quartile 3 (N=47) | Estradiol Quartile 4 (N=45) | |
|---|---|---|---|---|---|
| DEMOGRAPHICS | |||||
| Age, years, mean (SD) | 80.8 (5.3) | 80.9 (5.3) | 81.0 (5.0) | 81.3 (5.7) | 80.0 (5.0) |
| Ethnicity, % Caucasian | 81.6 | 82.6 | 89.1 | 83.0 | 73.3 |
| Education, years, mean (SD) | 14.3 (3.8) | 14.3 (4.3) | 15.1 (4.0) | 14.3 (3.3) | 13.7 (3.6) |
| Body Mass Index, kg/m2, mean (SD) | 26.9 (4.1) | 26.5 (3.6) | 27.4 (3.9) | 26.4 (4.2) | 27.3 (4.6) |
| Geriatric Depression Scale, mean (SD) | 2.2 (2.0) | 1.8 (1.8) | 2.5 (2.4) | 2.2 (2.0) | 2.1 (1.8) |
| COGNITIVE PERFORMANCE | |||||
| BIMC, total errors, median (range) | 1.0 (0–10) | 1.0 (0–10) | 1.0 (0–5) | 2.0 (0–7) | 1.0 (0–7) |
| FCSRT, free recall, mean (SD) | 30.1 (5.9) | 29.9 (6.9) | 29.7 (5.5) | 28.9 (6.1) | 32.0 (4.8) |
| Logical Memory, mean (SD) | 21.1 (7.0) | 20.7 (6.2) | 22.3 (6.9) | 20.7 (7.1) | 20.8 (7.9) |
| Trail Making Test part B, mean (SD) | 149.2 (76.9) | 155.6 (82.9) | 146.6 (80.2) | 138.9 (65.2) | 152.6 (77.3) |
| Block Design, mean (SD) | 26.5 (9.2) | 26.8 (9.0) | 25.3 (7.9) | 26.7 (11.0) | 27.2 (8.8) |
| MEDICAL HISTORY | |||||
| History of myocardial infarction, % yes | 16.8 | 17.8 | 21.7 | 4.3 | 22.2 |
| History of stroke, % yes | 12.0 | 8.9 | 10.9 | 12.8 | 13.3 |
| History of CABG, % yes | 17.4 | 15.6 | 28.3 | 10.6 | 13.3 |
| Summary history of any MI, stroke, or CABG, % yes | 35.3 | 33.3 | 45.7 | 23.4 | 37.8 |
| History of diabetes, % yes | 22.3 | 22.2 | 17.4 | 29.8 | 20.0 |
| History of hypertension, % yes | 59.8 | 71.1 | 56.5 | 55.3 | 55.6 |
| History of smoking, % yes* | 62.6 | 63.4 | 66.7 | 59.5 | 60.0 |
*
N=184 data available for total estradiol levels; N=171 data available for history of smoking.
Note: SD=standard deviation; BIMC=Blessed Information Memory Concentration test (scores range 0–33), total error score; FCSRT= Free and Cued Selective Reminding Test (scores range 0–48); LM=WMS-R Logical Memory immediate recall stories A and B (scores range 0–50); CABG=Coronary Artery Bypass Graft; MI=Myocardial Infarction