Table 4.

Summary of association results at functional polymorphisms in MMP genes in the GoKinD collection

Gene	SNP	Chr.	Position	Alleles (Minor/major)	Location	Reference(s)	Additive	P-value Dominant	Recessive
MMP-2	rs242866	16	54,069,038	A/G	−1575	Harendza S., et al. (2003) [11]	0.32	0.37	0.24
MMP-2	rs243865*	16	54,069,307	T/C	−1306	Price S.J., et al. (2001) [12]	0.91	0.90	0.24
MMP-3	rs3025058	11	102,221,162	5A/6A	−1612	Ye S., et al. (1996) [13], Ye S., et al. (1999) [36]	0.02	0.08	0.02
MMP-7	rs11568818*	11	101,906,871	C/T	−181	Jormsjo S., et al. 2000 [14]	0.98	0.87	0.88
MMP-7	rs11568819*	11	101,906,843	A/G	−153	Jormsjo S., et al. 2001 [15]	0.35	0.51	1.00
MMP-12	rs2276109*	11	102,251,001	C/T	−82	Jormsjo S., et al. 2000 [14]	0.76	0.77	0.92
MMP-13	rs2252070	11	102,331,749	C/T	−77	Yoon S., et al. 2002 [16]	0.09	0.09	0.36

P-values were calculated using stratified additive tests of association (adjusting for both gender and JDC/GWU strata) using the Cochran-Mantel-Haenszel test procedure and under both dominant and recessive genetic models. Imputed SNPs are indicated by asterisks. rs243866 and rs2252070 were genotyped on the Affymetrix 5.0 array. rs3025058 was genotyped using a Taqman assay. SNP positions are in reference to NCBI Build 36.1.