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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 1;21(9):2732–2735. doi: 10.1016/j.bmcl.2010.11.104

Scheme 2.

Scheme 2

Reagents: a) 3-pyrazoleboronic acid, Pd(PPh3)4, K2CO3, DMF, 100°C, 3h; b) MeI, K2CO3, DMF, 50°C, overnight; or Ar1X, CuI, K2CO3, trans-N,N′-dimethylcyclohexane-1,2-diamine, dioxane, 120°C, overnight; c) R2PhNH2, Pd(OAc)2, xantphos, Cs2CO3, dioxane, 130°C, 1h, microwave.