. Author manuscript; available in PMC: 2012 May 1.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 1;21(9):2732–2735. doi: 10.1016/j.bmcl.2010.11.104

Table 1.

JNK3 inhibition by analogues of 7–9.

Compds	X	R¹	R²	JNK3 IC₅₀ (μM)^a	p38 IC₅₀ (μM)^a
1	H	H	A	0.63	> 20
7	H	Me	A	1.45	nt
8	Cl	Me	A	0.86	nt
9	Cl	Me	B	0.73	nt

Values are means of three experiments, nt = not tested, All standard deviation ≤ 20%