. Author manuscript; available in PMC: 2012 May 1.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 1;21(9):2732–2735. doi: 10.1016/j.bmcl.2010.11.104

Table 2.

Inhibition of JNK3 by compounds 12–23.

Compds	X	R¹	R²	JNK3 IC₅₀ (μM)^a	p38 IC₅₀ (μM)^a
12	H	H	E	0.16	>20
13	Cl	H	E	0.07	>20
14	Cl	Me	E	0.13	>20
15	Cl	Me	D	0.16	>20
16	Cl	Me	B	0.20	>20
17	Cl	Me	C	0.60	>20
18	F	Me	E	0.16	>20
19	F	Me	D	0.34	>20
20	F	Me	C	0.20	>20
21	F	Me	F	0.48	>20
22	F	Me	B	0.16	>20
23	Me	Me	B	0.75	>20

Values are means of three experiments, All standard deviation ≤ 20%