. Author manuscript; available in PMC: 2012 May 1.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 1;21(9):2732–2735. doi: 10.1016/j.bmcl.2010.11.104

Table 4.

4-substituted pyrazole SAR

Compds	R²	R³	JNK3 IC₅₀ (μM)^a	p38 IC₅₀ (μM)^a
37	D	4-FPh	0.007	0.02
38	D	3-Py	0.11	1.14
39	E		0.15	0.19
40	E		0.39	> 20
41	E		0.39	> 20
42	D	n-Pr	1.40	> 20
43	D	Me	0.40	> 20

Values are means of three experiments, All standard deviation ≤ 20%