. Author manuscript; available in PMC: 2012 May 1.

Published in final edited form as: Gastroenterology. 2011 Feb 12;140(5):1427–1433. doi: 10.1053/j.gastro.2011.02.004

Table 2.

Aspirin and NSAID Use and the Risk of Diverticulitis and Diverticular Bleeding^a

	Non-users of Aspirin and NSAIDs	Regular Use of Aspirin only	Regular Use of NSAIDs only	Regular Use of Aspirin and NSAIDs
Person Years	367,223	273,233	96,726	120,609
Diverticulitis
Incident cases	288	313	148	190
Age-adjusted HR (95% CI)^b	1.0	1.32 (1.12–1.55)	1.87 (1.52–2.29)	1.85 (1.53–2.42)
Multivariate HR (95% CI)^c	1.0	1.25 (1.05–1.47)	1.72 (1.40–2.11)	1.65 (1.36–2.01)
Diverticular Bleeding
Incident cases	58	93	40	65
Age-adjusted HR (95% CI)^b	1.0	1.90 (1.36–2.65)	1.92 (1.27–2.91)	2.45 (1.69–3.53)
Multivariate HR (95% CI)^c	1.0	1.70 (1.21–2.39)	1.74 (1.15–2.64)	2.02 (1.38–2.96)

Regular use was defined as at least 2 times per week. Non-regular use was defined as less than 2 times per week.

Age-adjusted HRs adjusted for age (in years) and study period in 2-year intervals

Multivariate HR adjusted for age, study period, body mass index, dietary fat, fiber, red meat, nut, corn and total caloric intake, and physical activity