Figure 5.
Time course of UVB-induced whole-cell K+ currents from HCLE cells. The top panel shows the recording protocol in 10 mV, 250 ms steps from a holding potential of −80 mV to +120 mV before and immediately following UVB exposure. The graphs show UVB-induced increases in K+ currents recorded at intervals from 3 representative cells at a command voltage of +60 mV over periods of 45 – 90 minutes following UVB exposure. The 0 time currents were recorded before UVB treatment. In two cells UVB caused high amplitude current during the first 10–15 minutes after followed by a reduction in current which is maintained at levels well above untreated values.