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. Author manuscript; available in PMC: 2012 May 15.
Published in final edited form as: Free Radic Biol Med. 2011 Mar 11;50(10):1368–1381. doi: 10.1016/j.freeradbiomed.2011.02.021

Figure 14. Cannabidiol attenuates the TNF-α induced polymorphonuclear cells (PMN) adhesion to human liver sinusoidal endothelial cells (HLSEC).

Figure 14

Representative images and quantification of human neutrophil adhesion to activated human liver endothelial cells. Treatment of HLSEC cells with TNF-α (50 ng/ml) for 6 hrs markedly enhances PMN adhesion. CBD (1 μM) attenuates this enhanced PMN adhesion. Cannabinoid receptors antagonists/inverse agonists such as SR141716 (SR1 for CB1 receptor) and SR144528 (SR2 for CB2 receptor) at 1 μM could not prevent the CBD-mediated attenuation of TNF-α-induced PMN adhesion. Results are mean±SEM of n=4–6/group. *P<0.05 vs. vehicle; #P<0.05 vs. TNF-α.