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. Author manuscript; available in PMC: 2012 May 15.
Published in final edited form as: Free Radic Biol Med. 2011 Mar 11;50(10):1368–1381. doi: 10.1016/j.freeradbiomed.2011.02.021

Figure 6. Cannabidiol attenuates I/R-induced increased adhesion molecule expression and acute pro-inflammatory cytokine TNF-α response in the liver.

Figure 6

Panels A: Real-time PCR shows significant increase of hepatic adhesion molecule ICAM-1 mRNA level at 2 hours of reperfusion (IR 2h), which was further attenuated at 6 and 24 hours of reperfusion (I/R 6h and 24h). Pretreatment with CBD at 10 mg/kg significantly attenuates the I/R-induced increased hepatic ICAM-1 expression at all time points of the reperfusion studied (2, 6 and 24 hours).

Panels B: Real-time PCR shows significant increase of hepatic pro-inflammatory cytokine TNF-α mRNA level at 2 h of reperfusion (IR 2h), and a gradual decrease with time. Pretreatment with CBD at 10 mg/kg attenuates the I/R-induced increased hepatic TNF-α mRNA level at all time points of reperfusion studied (2, 6 and 24 hours).

Results are mean±SEM of 6–12 mice/groups. *P<0.05 vs. vehicle-sham group; #P<0.05 vs. corresponding vehicle-I/R mice.