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. Author manuscript; available in PMC: 2012 May 15.
Published in final edited form as: Free Radic Biol Med. 2011 Mar 11;50(10):1368–1381. doi: 10.1016/j.freeradbiomed.2011.02.021

Figure 8. Cannabidiol attenuates I/R-induced hepatic NF-κB activation and p38 MAPK and JNK phosphorylation.

Figure 8

Panel A: The gel shift assay demonstrates NF-κB activation at 2 and 6 hours of reperfusion (I/R 2h and I/R 6h) which was attenuated at 24 hours reperfusion (I/R 24h). CBD pretreatment at 10 mg/kg attenuates these activation at all time points of reperfusion studied.

Panel B: Marked increase in the p38MAPK and c-Jun N-terminal kinase (JNK) activation in I/R liver tissues of mice at 2 and 6 hours following I/R injury, which are attenuated by CBD pretreatment at 10 mg/kg. β-actin is used as loading control.