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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 9;21(9):2697–2701. doi: 10.1016/j.bmcl.2010.12.015

Table 1.

Structures and activities of analogs 13.

graphic file with name nihms262400u1.jpg
Cmpd R M1EC50 (μM)a %ACh Maxa
7 2-Cl 9.71 83
13a 3-Cl 5.82 96
13b 4-Cl >10 -
13c 2-OMe >10 -
13d 3-OMe 6.54 79
13e 4-OMe >10 -
13f 3-F 5.22 96
13g 3-Br 3.79 91
13h 3-CF3 >10 -
13i 3-CN >10 -
13j 3,5-diBr >10 -
13k 3,4-diCl >10 -
13l 4-CF3 >10 -
13m 4-OCF3 >10 -
13n 2-F >10 -
13o 2,4-diF >10 -
13p 2-Br-4-F >10 -
a

Average of at least three independent determinations.