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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 9;21(9):2697–2701. doi: 10.1016/j.bmcl.2010.12.015

Table 3.

Structures and activities of analogs 15.

graphic file with name nihms262400u3.jpg
Cmpd G R1 R2 R4 R6 M1 EC50 (μM)a %ACh Maxa
15a A H H F H >10 -
15b Br H H F H >10 -
15c Cl H H F H >10 -
15d Br F H H H 5.37 103
15e A F H H H 1.85 102
15f Cl H F H H 5.10 56
15g Br H F H H >10 -
15h A H F H H 4.40 103
15i A H H H F 3.07 96
15j Br H H H F 1.38 84
a

Average of at least three independent determinations.