Table 3.

Summary of TSU-68 pharmacokinetic data

Dose	mg/m2 (n)	T max (h)	C max (mg/ml)	AUC0–t (h)	T 1/2 (h)
b.i.d.
1st	200 (3)	3.000 ± 1.000	11.213 ± 1.1470	55.19 ± 5.356	2.365 ± 0.8600
	400 (6)	2.667 ± 0.8165	17.088 ± 6.5872	76.44 ± 23.07	2.935 ± 0.6925
	500 (3)	4.000 ± 1.732	22.538 ± 10.019	102.8 ± 45.57	2.351 ± 0.5992
3rd	200 (3)	3.500 ± 2.291	6.0000 ± 0.67065	33.28 ± 4.329	2.707 ± 0.4712
	400 (6)	2.667 ± 0.8165	8.2905 ± 2.7224	40.38 ± 10.63	3.450 ± 1.366
	500 (3)	4.333 ± 1.528	8.7873 ± 2.9245	45.74 ± 14.59	3.334 ± 1.161
55th	200 (3)	2.000 ± 0.8660	6.4597 ± 1.9125	28.71 ± 1.601	3.453 ± 0.9825
	400 (6)	2.250 ± 0.5000a	8.5832 ± 4.5463a	31.97 ± 11.32a	2.620 ± 0.4410b
	500 (3)	3.333 ± 2.309	9.3587 ± 5.7174	34.09 ± 12.44	2.958 ± 0.7176
56th	200 (3)	2.667 ± 1.155	4.7870 ± 0.52566	32.20 ± 1.543	3.469c
	400 (6)	2.375 ± 0.7500a	8.4130 ± 5.8740a	36.86 ± 20.31a	2.595 ± 0.5267
	500 (3)	3.167 ± 1.443	7.5103 ± 3.4614	43.19 ± 18.72	1.820d
t.i.d.
1st	200 (6)	3.083 ± 1.429	10.997 ± 5.5284	37.04 ± 18.24	2.035 ± 0.4607b
	400 (6)	3.417 ± 1.201	12.450 ± 5.7597	41.55 ± 21.60	2.610d
2nd	200 (6)	3.667 ± 1.366	7.0053 ± 2.4124	31.52 ± 12.52	2.986c
	400 (6)	3.000 ± 1.789	9.3387 ± 4.5090	42.01 ± 18.90	2.406 ± 1.144b
82nd	200 (6)	2.667 ± 0.983	4.6755 ± 1.4910	15.16 ± 4.886	1.459c
	400 (6)	3.833 ± 1.438	6.0472 ± 2.4067	17.31 ± 6.867	1.990d
84th	200 (6)	2.000 ± 1.049	3.8457 ± 2.9842	24.75 ± 13.69	4.773 ± 2.221e
	400 (6)	2.917 ± 1.201	4.7810 ± 1.9514	31.65 ± 16.13	2.226c

(Mean ± SD, N = 6: 200 mg/m² of t.i.d. and 400 mg/m², N = 3: 200, 500 mg/m² of b.i.d.)

^a N = 4, ^b N = 3, ^c N = 2, ^d N = 1, ^e N = 5