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. 2011 Apr 4;193(1):21–29. doi: 10.1083/jcb.201101046

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© 2011 Kehat et al.

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Figure 4. — HDAC4 regulates spatial chromatin organization. (A) Confocal FISH of selected loci (green dots, arrows) with nuclear Topro3 counterstain (blue) in NRVMs showing predominant peripheral nuclear localization of the Nppb, Acta1, Cacna1c during control conditions, a shift to a more central nuclear position under HDAC4 (HD4) overexpression, and reversal of the HDAC4 effect by expression of Nup155ΔC. In contrast, the Pln locus demonstrates a reverse pattern. (B) Quantitative summary of the FISH data showing the percentage of peripheral nuclear FISH signals (white bar) versus central nuclear signals (black bar). *, P < 0.001; significance of HDAC4-expressing vs. control and HDAC4+ Nup155ΔC, n = 250.