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. 2011 Mar 10;25(5):847–858. doi: 10.1210/me.2010-0508

Fig. 6.

Fig. 6.

Both AICAR and low glucose activate a nonspecific cation current in GnRH neurons. A, AICAR and low glucose increased holding current at −70mV. *, P < 0.05 by paired t test. B, AICAR and low glucose decreased input resistance. *, P < 0.05 by paired t test. C (top), Step protocol used to generate current-voltage data. C (bottom), representative traces before (control), during AICAR, and after 10 min of washout (wash) (every other step shown for clarity). AICAR generated a current with a reversal potential of around −50 mV that was at least partially reversible upon washout (wash). D and E, Representative steady-state current-voltage relationships before (closed circles) and after (open circles) AICAR (D) or low glucose (E) and subtracted current (open triangles). Washout current-voltage plot is shown in gray. G, Mean ± sem AICAR-induced (subtracted) current in cells with (n =11) and without (n = 8) TTX. F, Mean ± sem low-glucose-induced (subtracted) current in cells with (n = 4) and without (n = 4) TTX. The current was similar in the presence and absence of TTX. ms, Millisecond.