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Intrinsic clearance (Vmax/Km) values for CYP2B6 and CYP2D6 for the formation of the different oxidative metabolites of anandamide
The kinetic data used to calculate the intrinsic clearance values for CYP2B6 were obtained from Table 2 and for CYP2D6 from Snider et al. (2008).
| Vmax/Km | 20-HETE-EA | 14,15-EET-EA | 11,12-EET-EA | 8,9-EET-EA | 5,6-EET-EA |
|---|---|---|---|---|---|
| CYP2B6 | N.D. | 0.57 | 5.73 | 2.58 | 3.38 |
| CYP2D6 | 2.85 | 0.46 | 0.42 | 0.76 | N.D. |
N.D., not detected.
