Fig. 1.

Tissue partition coefficients measured using the cocktail approach were not significantly different from those measured using an individual corticosteroid solution and correlated positively with lipophilicity. A, sclera and choroid-RPE tissue/PBS (pH 7.4) partition coefficients of six corticosteroids at 0.4, 2, and 10 μg/ml in a cocktail solution. B, sclera and choroid-RPE tissue/PBS (pH 7.4) partition coefficients of dexamethasone alone at 0.4, 2, and 10 μg/ml. Correlation of lipophilicity (logD; pH 7.4) with sclera (C) and CRPE tissue/PBS (pH 7.4) (D) partition coefficients in cocktail mixture at 0.4, 2, 10 μg/ml. Data are expressed as the mean ± S.D. for n = 5.