Fig. 8.

Correlation between ex vivo or in vivo tissue concentrations obtained after transscleral delivery from corticosteroid suspensions in Brown Norway rats with in vitro bovine tissue/PBS partition coefficients. A and C, correlations between ex vivo tissue concentrations and tissue partition coefficients for sclera and choroid-RPE, respectively. B and D, correlations between in vivo tissue concentrations and tissue partition coefficients for sclera and choroid-RPE, respectively. Data are expressed as the mean ± S.D. (n = 4 for ex vivo and in vivo studies and n = 5 for tissue partition studies). □, ex vivo or in vivo tissue levels (micrograms per gram of tissue) without normalization to corticosteroid solubility in the cocktail suspension; ▴, ex vivo or in vivo tissue levels (micrograms per gram of tissue per microgram per milliliter) normalized to corticosteroid solubility in the cocktail suspension.