Fig. 3.

The development of hepatic bilirubin clearance for UGT1A1 in pediatric liver. A, the development using the well stirred model with allometric scaling. Apparent adult clearance reached a plateau at 0.0070 l · h⁻¹ · kg⁻¹. The 90th percentile of adult clearance was reached at 3.0 years of age. B, the development using the parallel-tube model with allometric scaling. Apparent adult clearance reached a plateau at 0.0070 l · h⁻¹ · kg⁻¹. The 90th percentile of adult clearance was reached at 2.8 years of age. C, the development using the Simcyp and well stirred model. The model showed a similar plateau at 0.0079 l · h⁻¹ · kg⁻¹. The 90th percentile of adult clearance was reached at 2.6 years. D, the development using the Simcyp and parallel-tube model. Clearance reached a plateau at 0.0079 l · h⁻¹ · kg⁻¹. The 90th percentile of adult clearance was reached at 2.5 years. Allometric models are represented by ● and solid lines, whereas Simcyp pediatric models are ○ and dashed lines. Pooled adult clearance is shown as the dotted lines. The model is unweighted and constrained by medium convergence criteria requiring five consecutive iterations of the fit to change the sum-of-squares by less than 0.0001%, and any outlier is removed as determined by the residuals.