Skip to main content
. Author manuscript; available in PMC: 2011 Apr 26.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2007 Jun 21;16(7):1510–1516. doi: 10.1158/1055-9965.EPI-07-0137

Figure 1.

Figure 1

Haplotype tag SNPs (htSNPs) and pair-wise linkage disequilibrium (LD) as measured by R2 in a 200 kb-region surrounding (and including) the BRCA1 gene. Blocks represent consecutive sets of SNPs for which common haplotypes (with a frequency of at least 3%) accounted for at least 80% of all predicted haplotypes. Two SNPs in the first block, rs2271539 and rs691144, and four SNPs in the second block, rs1799966, rs3737559, rs1799950, and rs799923, distinguished 94% and 96%, respectively, of haplotypes inferred within the first and second blocks. SNP rs7223952, which is not present in the HapMap database, is not an htSNP but is located in the second block and was in high LD with htSNP rs1799966 (R2=0.94). Data are based on 323 unrelated, unaffected non-Hispanic white men from our family-based association study.