Table 2.
Allele frequencies for SNPs in or near the BRCA1 gene by prostate cancer affection status
| Minor allele frequency in | ||||||
|---|---|---|---|---|---|---|
| Gene | SNP name | Location | Position* | Major>minor allele | Affected men (n=434) | Unaffected men (n=383) |
| RPL27 | rs2271539 | Intron 2 | −43.936 | T>C | 0.28 | 0.30 |
| IFI35 | rs691144 | Intron 1 | −31.236 | G>A | 0.19 | 0.19 |
| Intergenic | rs7223952 | - | 0 | A>G | 0.29 | 0.31 |
| BRCA1 | rs1799966 | Exon 17 | 28.209 | T>C | 0.28 | 0.30 |
| BRCA1 | rs3737559 | Intron 13 | 39.419 | G>A | 0.06 | 0.08 |
| BRCA1 | rs1799950 | Exon 11 | 51.596 | A>G | 0.08 | 0.06 |
| BRCA1 | rs799923 | Intron 6 | 57.046 | G>A | 0.28 | 0.26 |
*
Kilobase position relative to SNP rs7223952 according to the reference sequence (UCSC Genome Browser, NCBI Build 36.1, March 2006).