Table 4.

Number of families and men with and without prostate cancer from Genome-Wide Scan (GWS) and Discordant Sibling Pair (DSP) studies

	GWS study	DSP study	Overlap
All:
Families	154	323	74
Affected men	411	434	119
Unaffected men	72	383	57
Arg356 carrier*:
Families	25	61	13
Affected men	44	71	15
Unaffected men	8	47	7

NOTE: All families were enrolled in the University of Michigan Prostate Cancer Genetics Project (PCGP). GWS families were recruited for the purpose of conducting linkage analyses and were previously genotyped for 15 microsatellite markers on chromosome 17(6). DSP families were recruited for the purpose of conducting family-based association tests as described elsewhere(12). Numbers correspond to non-Hispanic white families and men, which represented >90% of all families and men from each study.

^*Carriers of the Arg356 allele of BRCA1 Gln356Arg (or equivalently, the minor allele at SNP rs1799950); excludes families with no affected male carriers.