Appendix 2.

Fluid balance technique

Variable	Alternate Approach
Intake	Variable
Output (non-CRRT related)	Variable
Ultrafiltration rate	Fixed to achieve target effluent volume
Substitution fluid rate	It varies to achieve negative, zero, or positive fluid balance
Fluid balance	It is achieved by adjusting amount of substitution fluid
Effluent volume	Fixed, to achieved desired solute clearance and allow flexibility in accommodating varying intake

The alternate technique for fluid balance in CRRT in which a fixed ultrafiltration rate is set to achieve and effluent volume that meets the desired clearance. Modified from 21.