Table 2.

Treatment effects according to different measures of CrCl

Method of Measurement	Control		Treatment		Difference		P
	Estimated Mean	SEM	Estimated Mean	SEM	Estimated Mean	SEM
4V-MDRD CrCl (ml/min per 1.73 m2)	5.19	0.13	5.67	0.1	0.48	0.16	<0.01
6V-MDRD CrCl (ml/min per 1.73 m2)	5.42	0.12	6.14	0.09	0.73	0.15	<0.001
Measured pCrCl (ml/min per 1.73 m2)	4.57	0.045	5.65	0.05	1.08	0.06	<0.001
SCr (mg/dl)	11.44	0.17	10.39	0.16	−1.05	0.22	<0.001
Total mCrCl (ml/min per 1.73 m2)	5.37	0.10	6.24	0.07	0.87	0.12	<0.001

Values represent time-averaged values over the course of study. P values compare the differences in treatment versus control.