Table 4.
Pooled multivariatea relative risks (95% confidence intervals) of colon cancer for a 100 mcg/d increment in total folate intake by alcohol consumption, methionine intake, and smoking statusb
| Number of cases | RR (95% CI) | p-Value, test for interaction | |
|---|---|---|---|
| Alcohol consumption (g/d)c | |||
| 0 | 1,681 | 1.00 (0.98–1.02) | 0.22 |
| >0– <15 | 2,136 | 0.98 (0.96–1.00) | |
| ≥15 | 838 | 0.96 (0.92–1.00) | |
| Methionine intake | |||
| Tertile 1 | 1,639 | 0.99 (0.96–1.02) | 0.72 |
| Tertile 2 | 1,542 | 0.97 (0.95–1.00) | |
| Tertile 3 | 1,484 | 0.98 (0.96–1.01) | |
| Smoking status | |||
| Neverd | 2,009 | 0.99 (0.97–1.01) | 0.08 |
| Pastd | 1,775 | 0.99 (0.96–1.01) | |
| Current | 815 | 0.94 (0.90–0.98) | |
Relative risks were adjusted for the same covariates as listed in Table 2
The Canadian National Breast Screening Study, Prospective Study on Hormones, Diet and Breast Cancer, and Swedish Mammography Cohort were excluded from these analyses because data were not available on multivitamin use at baseline
The New York University Women’s Health Study was excluded from these analyses because this study did not assess alcohol consumption
The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study was not included in this stratum because this study only includes current smokers