. Author manuscript; available in PMC: 2011 Apr 26.

Published in final edited form as: J Invest Dermatol. 2010 Feb 4;130(5):1279–1287. doi: 10.1038/jid.2009.440

Table 1.

Degree of nuclear sAC staining in examples of keratinocyte hyperproliferative skin disease

	Expression pattern
	+	+/−	−
Verruca vulgaris	6	0	3
Molluscum contagiosum	0	0	7
Seborrheic keratosis	6	1	3
Epidermolytic hyperkeratosis	0	0	4
Acanthosis nigricans	0	3	2
Actinic keratosis	4	1	0
Bowenoid papulosis with high-grade dysplasia, +HPV in situ	1	3	7
Squamous cell carcinoma in situ, no dermal involvement, sun-exposed sites	9	1	3
Squamous cell carcinoma, invasion of dermis, both sun-exposed and non-exposed sites	3	1	2
Basal cell carcinoma	0	0	10
Pityriasis rubra pilaris	0	1	2
Psoriasis vulgaris	5	5	0
Psoriasis pustular	3	0	0
Psoriasis guttate	4	0	0

Abbreviation: sAC, soluble adenylyl cyclase.

−: Approximately 10% of keratinocytes have nuclei positive for sAC and sAC staining is strongly cytoplasmic (equivalent to normal skin); +/−: 10–70% of keratinocytes have nuclei positive for sAC and decreased cytoplasmic sAC staining in keratinocytes with sAC nuclear staining; +: >70% of keratinocytes have nuclei positive for sAC, with barely detectable cytoplasmic sAC staining.