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Mediators of the extrinsic pathway of PCD by Fas and TNFR-1 signaling. (a) The protein domain structures of Fas and TNFR-1. Each receptor has cysteine-rich domains (CRD) in the ligand binding region, characteristic of members of the TNF superfamily of receptors. There is a death domain in the intracellular portion of each receptor. (b) Fas death signaling patheways. (c) TNFR-1 signaling pathways. See text for details.
