Table 4.
Univariate and Multivariate Predictors of Varenicline Adherence
| Number of days varenicline taken |
Less purposeful nonadherence |
|||||
| Outcome | Univariate |
Multivariate | Univariate |
Multivariate | ||
| Predictor | r2 | p value | p value | r2 | p value | p value |
| Older age at baseline | .0077 | .0057 | .0347 | .0108 | .0020 | .0132 |
| Male gender | −.0000 | .8384 | .0240 | .0001 | .0106 | |
| More years of formal schooling | .0027 | .1017 | .3186 | −.0046 | .0454 | .0662 |
| Fewer baseline cigarettes per day | .0003 | .5661 | −.0082 | .0075 | .0981 | |
| Lower baseline FTND | .0028 | .1080 | .2027 | −.0009 | .3785 | |
| No other smokers in the home | .0025 | .1181 | .1957 | .0002 | .6742 | |
| Lower baseline depression | .0023 | .1315 | .3693 | .0043 | .0522 | .3215 |
| Greater varenicline adherence self-efficacy | .0050 | .0262 | .1941 | .0087 | .0055 | .0110 |
| Less negative treatment outcome expectations | .0026 | .1134 | .6223 | .0009 | .3811 | |
| More positive treatment outcome expectations | .0000 | .9116 | .0000 | .9102 | ||
| Lower initial medication side effect symptom severity | .0036 | .0666 | .4343 | .0470 | .0001 | .0001 |
| Lower initial nicotine withdrawal symptom severity | .0076 | .0082 | .0896 | .0216 | .0001 | .0774 |
Note. Multivariate models included all variables with a univariate p value <.15. Because of missing data, only N = 854 cases were used for the multivariate model of days taken (overall model r2 = .0224, p = .0234) and 830 cases were used for the multivariate model of less purposeful nonadherence (overall model r2 = .0847, p < .0001). Higher scores on the Medication Adherence Questionnaire purposeful nonadherence subscale reflect less purposeful nonadherence (i.e., greater adherence). FTND = Fagerström Test for Nicotine Dependence.