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Cathepsin L (Ctsl) deficiency potentiates premalignant neoplastic progression in K14–HPV16 mice. (a) Ear skin from HPV16/Ctsl+/+ and HPV16/Ctsl−/− mice was histologically evaluated for the occurrence of dysplasia at 8, 16 and 24 weeks of age (each group n = 8–10). (b) Immunohistochemical staining of the proliferation marker Ki67 in ear skin from HPV16 mice. (c) Quantification of Ki67 staining in the subcorneal epidermal layers. Bars indicate 50 µm.
