Table 2. Putative virulence genes associated with complicated infections.
Clinical Outcome | |||||||
Common Gene Name | Locus | Source Strain | Sum Hitsa | Array P-value For Associationb | PCR P-value For Associationc | P-value After Adjust for MRSAd | Simple Agreement |
transposase/integrase | VRA0002 | Michigan-VRSA | 13 | 0.0008 | 0.0007 | 0.5604 | 0.927* |
transposase/integrase | SA1483 | N315 | 3 | 0.0004 | <0.0001 | 0.0332 | 0.899* |
thymidylate synthase | VRA0005 | Michigan-VRSA | 1 | 0.0147 | 0.152 | 0.6199 | 0.89* |
hypothetical phage protein | SAS0928 | MSSA476 | 1 | 0.0127 | 0.0018 | 0.2105 | 0.99* |
prophage amidase/cell wall autolysin | SA0389 | COL | 2 | 0.0112 | 0.0019 | 0.4321 | 0.867* |
conserved hypothetical protein | SA0329 | COL | 1 | 0.0205 | 0.1916 | 0.4568 | 0.838* |
hypothetical phage protein | SAR1546 | MRSA252 | 2 | 0.0227 | 0.0001 | 0.0261 | 0.581 |
hypothetical phage protein | SAR1502 | MRSA252 | 1 | 0.0131 | 0.0019 | 0.1661 | 0.768* |
prophage amidase/cell wall autolysin | MW1380 | MW2 | 2 | 0.0124 | 0.0029 | 0.2461 | 0.853* |
phage regulatory protein | SAR1522 | MRSA252 | 4 | 0.002 | n.d. | n.d. | n.d. |
hypothetical protein | MW1385 | MW2 | 2 | 0.0022 | 0.0011 | 0.1764 | 0.994* |
conserved hypothetical protein | SA0338 | COL | 1 | 0.0085 | <0.0001 | 0.0132 | 0.988* |
hypothetical protein | SA0397 | N315 | 3 | 0.0049 | 0.0219 | 0.4199 | 0.755* |
putative regulatory protein | SAR1555 | MRSA252 | 1 | 0.0146 | 0.0079 | 0.7332 | 0.908* |
(a)Sum Hits: the number of times this probe hybridized to a part of the sequenced genomes.
(b)P-value for clinical association from aCGH results.
(c)P-value for clinical association from PCR validation.
(d)P-value for gene association with sick outcome after adjusting for MRSA status.
*Value greater than 0.60 indicates PCR results are in simple aggrement with a CGH results.