Table 3. Relative risk of death from cardiovascular disease according to waist circumference and body mass index.

	Death from any cardiovascular disease
Waist circumference (cm)	<80 (women); <94 (men)	80–87 (women); 94–101 (men)	88–95 (women); 102–117 (men)	≥96 (women); ≥118 (men)	P for trend
Person-years	814,082	528,937	544,579	73,404
Number of deaths	2,241	1,818	2,149	460
Age-adjusted relative risk	1.0	1.18 (1.11–1.26)	1.42 (1.34–1.51)	2.60 (2.35–2.88)	<0.0001
Multivariate relative risk	1.0	1.17 (1.09–1.25)	1.28 (1.18–1.38)	1.82 (1.59–2.08)	<0.0001
Body mass index (kg/m2)	18.5–24.9	25.0–29.9	30.0–34.9	≥35.0
Person-years	778,400	836,885	269,391	76,326
Number of deaths	2,160	2,922	1,173	413
Age-adjusted relative risk	1.0	1.11 (1.05–1.18)	1.52 (1.42–1.63)	2.37 (2.13–2.63)	<0.0001
Multivariate relative risk	1.0	1.14 (1.08–1.21)	1.53 (1.43–1.65)	2.37 (2.13–2.64)	<0.0001

The multivariate models used person-time as the underlying time metric and included the following covariates: age at entry (continuous), sex (male, female), race/ethnicity (white, black, Hispanic, Asian), smoking status (never, former, current), and alcohol intake (0, <1, <3, ≥3 drinks per day). The analyses of waist circumference were additionally adjusted for body-mass index (18.5–24.9, 25.0–29.9, 30.0–34.9, ≥35.0 kg/m²).