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. 2011 Apr 26;6(4):e19194. doi: 10.1371/journal.pone.0019194

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Braidy et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) PARP activity was determined in aging tissue using a spectrophotometric assay. All values are means ± S.E from tissue obtained from eight different rats for each age group. Significance ^*p<0.01 compared to 3 month old rats. (B) Western blotting for poly(ADP-ribose) in (i) liver, (ii) heart, (iii) kidney, and (iv) lung with aging using anti-Poly(ADP-ribose) (10H) antibody. The blots shown are representative tracings of an experiment done eight times. Graphs are mean ± S.E from tissue obtained from eight different rats for each age group. Each bar of the quantification graph represents the corresponding band for each age group. Significance ^*p<0.01 compared to 3 month old rats. (C) Immunodetection for poly(ADP-ribose) in the liver, heart, kidney and lung from 3 month, 12 month and 24 month old rats. Poly(ADP-ribose) (green) and DAPI (blue). Higher immunoreactivity for poly(ADP-ribose) was observed in 12 and 24 month old rats compared to 3-month old rats.