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A simplified overview of the GABA degradation pathway. The boxed abbreviations indicate the enzyme responsible for conversion of the substrate at that stage of the pathway (GAD – glutamate decarboxylase; GABA-T – GABA transaminase; OR – oxidoreductase (or aldo-keto reductase); SSADH – semialdehyde dehydrogenase). It has also been suggested that SSADH may play a role in conversion of GABA to SSA (Kim et al. 2009).
