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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Hepatology. 2011 May;53(5):1662–1675. doi: 10.1002/hep.24253

Figure 1.

Figure 1

Figure 1

A. Representative H&E staining images of small intestinal (ileum shown) Paneth cells containing dense eosinophilic granules within their apical cytoplasm (400X magnification). Hepatic IR resulted in small intestinal Paneth cell degranulation (B and C) in 5 hrs compared to sham-operated animals (A). Inserts show enlarged images of Paneth cells showing degranulation into the crypt lumen. Representative of 5 experiments. B. Representative electron micrograph images of small intestinal Paneth cell degranulation (indicated by *) 5 hrs after hepatic IR (4000X and 6000X magnification shown) compared to sham-operated mice (3000X magnification). The crypt lumen from sham-operated mice was devoid of Paneth cell granules. Representative of 3 experiments. N = nucleus of Paneth cells. SG = secretory granules of Paneth cells. SC = stem cells located above the Paneth cells.