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Cytokine/chemokine production profile of DC following delivery of ovarian cancer lysates in soluble or NP-associated form. Ovarian cancer lysate encapsulated in NP activates DC to produce pro-inflammatory cytokines such as IL-1β, IL-6, IFNγ, TNFα, G-CSF and RANTES, an effect not associated with soluble Ag delivery or non-specific NP stimulation [media= DC only, NP= DC loaded with empty nanoparticle; L= DC loaded with equimolar soluble lysate; NPL= DC loaded with NP-encapsulated lysate].
