Table 1.
Genetic Polymorphisms Surpassing Criterion for Genome-Wide Significant Association (p≤5×10−8) with Psychiatric Disorders
| Disorder | P-Value | SNP | Gene | Location | Effect on ASR-Binding Motif(s)* |
|---|---|---|---|---|---|
| Attention-deficit/hyperactivity disorder | 1 × 10−8 | rs7995215 | GPC6 | Intron | (>)ASF/SF2; (+)hnRNPU; (>)SC35 |
| Attention-deficit/hyperactivity disorder | 1 × 10−8 | rs864643 | MOBP | Intron | (>)ASF/SF2 |
| Alcohol dependence | 1 × 10−8 | rs7590720 | --- | Intergenic | |
| Autism | 4 × 10−8 | rs4141463 | MACROD2 | Intron | (−)hnRNPC1/C2; (<)hnRNPI; (>)HuR; (−)SRp55; (>)Sxl; (>)U2AF65 |
| Autism | 2 × 10−10 | rs4307059 | --- | Intergenic | |
| Bipolar disorder | 9 × 10−9 | rs10994336 | --- | Intergenic | |
| Bipolar disorder | 2 × 10−8 | rs1012053 | DGKH | Intron | (+)ASF/SF2; (−)hnRNPK; (>)SRp40; (>)SRp55 |
| Bipolar disorder and major depressive disorder | 3 × 10−8 | rs1006737 | CACNA1C | Intron | (+)hnRNPF; (+)hnRNPH; (>)hnRNPU; (>)SRp40; (>)SRp55; (+) Tra2Beta |
| Bipolar disorder and major depressive disorder | 2 × 10−9 | rs2251219 | PBRM1 | Exon | (+)hnRNPF; (+)hnRNPH; (−)Tra2Beta |
| Bipolar disorder and schizophrenia | 6 × 10−9 | rs11789399 | --- | Intergenic | |
| Bipolar disorder and schizophrenia | 4 × 10−8 | rs12201676 | --- | Intergenic | |
| Narcolepsy | 3 × 10−8 | rs2858884 | --- | Intergenic | |
| Narcolepsy | 3 × 10−22 | rs1154155 | TRAA | Exon | (>)ASF/SF2; (−)hnRNPG; (<)SR9GB; (>)SRp55; (−)Tra2Beta |
| Nicotine dependence | 6 × 10−20 | rs1051730 | CHRNA3 | Exon | (−)SRp20; (<)SRp40; (<)SRp55 |
| Schizophrenia | 1 × 10−12 | rs6932590 | --- | Intergenic | |
| Schizophrenia | 2 × 10−10 | rs3131296 | NOTCH4 | Intron | (+)ASF/SF2; (<)SRp40; (<)SRp55 |
| Schizophrenia | 2 × 10−9 | rs12807809 | --- | Intergenic | |
| Schizophrenia | 4 × 10−9 | rs9960767 | TCF4 | Exon | (+)SRp40; (>)SRp55 |
| Schizophrenia | 1 × 10−8 | rs13194053 | --- | Intergenic |
*
(+) introduces; (−) abolishes; (>) strengthens; (<) weakens