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. Author manuscript; available in PMC: 2012 Mar 20.
Published in final edited form as: Genesis. 2010 Dec 22;49(1):10–23. doi: 10.1002/dvg.20686

Table 3.

Pax3Sp/+; Wnt1-Cre; Foxd3flox/− Compound Mutant Embryos Die at Midgestation

Mutant
Control
Wnt1-Cre;
Foxd3flox/− 		Wnt1-Cre;
Pax3Sp/+;
Foxd3flox/− 		Wnt1-Cre;
Pax3Sp-d/+;
Foxd3flox/−
Alive/total %
Alive		 Alive/total %
Alive		 Alive/total %
Alive
11.5 dpc 8/8 100 2/3 67 2/2 100
12.5 dpc 10/10 100 3/5 60 3/6 50
13.5 dpc 7/7 100 1/7 14 1/6 17
≥ 14.5 dpc 19/19 100 0/13 0 0/18 0

Deletion of Foxd3 from the NC in two independent Pax3 heterozygous mutant backgrounds resulted in midgestational lethality and a 100% penetrant persistent truncus arteriosus, independent of Cre line. All mutant embryos examined had a PTA.