Skip to main content
. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Ann Neurol. 2011 Mar 9;69(5):878–891. doi: 10.1002/ana.22299

Figure 3. Immunization with PLP results in transient increase in the SVZ cell proliferation.

Figure 3

SJL/J mice immunized with PLP 139–151 developed relapsing-remitting EAE. (a) Representative graph of the clinical course and the timing of BrdU injection and timing of sacrifice (indicated by down arrows). (b) BrdU+ cells in the forebrain during different phases of disease. The figure shows the corner of the lateral wall (LV), the SVZ and corpus callosum (CC). (c) Number of BrdU+ positive cells/mm2 in the corpus callosum in different phases of disease with no washout (*p<0.0005, **p=0.0055 versus control); 8 days wash out (*p<0.0005 versus control) and 28 days wash out (*p=0.0129, **p=0.0002 versus control) n=4 mice/ group. (d) Number of BrdU+ positive cells/mm in the lateral wall of the lateral ventricle with no washout (*p<0.002 vs. control); 8 days wash out (*p=0.0009 vs. control); 28 days wash out (*p=0.0314 versus control) n=4 mice/group. (e) Electron microscopy image from the corpus callosum (CC) of a normal control (left panel) and EAE (right panel). Astrocytic fibers indicated by arrows are enlarged during relapse. (scale bar in b represents 5 μm).