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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Ann Neurol. 2011 Mar 9;69(5):878–891. doi: 10.1002/ana.22299

Figure 7. Minocycline treatment ameliorates EAE and improves repair.

Figure 7

(A) Clinical course of animals treated with Minocycline starting on day 20 post-immunization. Disease grade is significantly lower in minocycline treated (circles) versus PBS treated (black squares) between days 20 and 55. (B) Number of forebrain lesions *p=0.0069, n=4 animals/group. (C) Labeling index of Sox-2+ cells in the SVZ after treatment with minocycline compared with PBS (*p=0.0423), labeling index of NG2+ cells (*p<0.0001), number of CNPase/BrdU+ cells (*p=0.0078), and mean pixel intensity of GFAP in the corpus callosum (*p=0.0077) (n=4 mice/group). (D) High-resolution 2.5-dimensional image of the MBP intensity in the corpus callosum (left panels). Quantification of the pixel intensity of MBP in control (black line) versus acute EAE (red line) and in late relapse after treatment with minocycline (blue line) compared to PBS treated mice (black line) *p<0.0001 (right panels).