Skip to main content
. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Ann Neurol. 2011 Mar 9;69(5):878–891. doi: 10.1002/ana.22299

Figure 8. Minocycline reduces toxicity of activated microglia to neural and oligodendrocyte progenitors.

Figure 8

A) MAP+ cells counted after 5 days of NSC differentiation in the presence of microglia supernatants from unstimulated microglia (HL-1 medium), IFN-γ treated microglia dose response showing a dose-response decrease in MAP+ cells. B) minocycline treatment of microglia reverses the deleterious effect of IFN-g stimulation on MAP+ cell survival. C) NG2+ cell survival after exposure to microglia supernatants stimulated with IFN-γ, showing a dose response decrease in NG2+ cells. D) minocycline treatment of microglia reverses the deleterious effect of IFN-γ stimulation on NG2+ cell survival. (*p<0.05, ***p<0.0001)