Fig. 2.

Simulation of propofol concentrations and response using COMFORT-B score versus time based on developed PK and PD models, after administration of different doses of propofol (0, 18, 30, and 36 mg/h) for a 10-kg and a 5-kg non-ventilated infant in the first night at the Intensive Care Unit following craniofacial surgery. Target COMFORT-B scores are between 12 and 14 preferably. Reproduced from [Peeters MY, Prins SA, Knibbe CA, DeJongh J, van Schaik RH, van Dijk M, et al. Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery. Anesthesiology 2006 Mar;104(3):466-74.]