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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Hepatology. 2011 May;53(5):1685–1695. doi: 10.1002/hep.24206

Figure 1.

Figure 1

Cre recombination efficiency in Alfp-Cre x Rosa26-YFP mouse livers is high. Representative split color and merged panels from immunostaining of liver sections following 3 weeks of DDC treatment. (A-D) YFP (Cy5, green) nearly completely co-localizes with K19 staining (Cy3, red). (YFP+K19)/K19 ratio = 1041 cells/1044 cells (99.7%). (E-H) YFP (Cy5, green) and A6 (Cy3, red). (YFP+A6)/A6 ratio = 903 cells/916 cells (98.6%). (I-L) YFP (Cy5, green) and HNF4α (Cy3, red). (YFP+HNF4α)/HNF4α ratio = 899 cells/905 cells (99.3%). Similar co-localization between YFP and either K19 or HNF4α was observed for BDL and CCl4 models (not shown). Blue = DAPI; * = representative bile ducts; v = portal vein. Scale bar = 10 μm.