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Dissociation binding constants (KD) and thermodynamic parameters for neomycin binding to N1, R23 and N1(R23) at 37°C
| Aptamer | KD (nM) | ΔG (kcal/mol) | ΔH (kcal/mol) | –TΔS (kcal/mol) |
|---|---|---|---|---|
| N1-3/0-CUU | 9.2 ± 1.3 | −11.4 ± 0.1 | −44.5 ± 0.1 | 33.1 ± 0.0 |
| R23 | 34.1 ± 2.1 | −10.6 ± 0.0 | −33.6 ± 0.4 | 23.0 ± 0.4 |
| N1(R23) | 9.5 ± 0.3 | −11.4 ± 0.0 | −38.1 ± 0.3 | 26.7 ± 0.2 |
Parameters extracted from ITC measurements (Figure 3 and Supplementary Figure S2).
